Download Aplastic Anemia: Pathophysiology and Treatment by Hubert Schrezenmeier, Andrea Bacigalupo PDF

By Hubert Schrezenmeier, Andrea Bacigalupo

This e-book takes account of the latest findings in laboratory examine and scientific trials to supply a accomplished and up to date reference at the pathophysiology, epidemiology, analysis and therapy of obtained and inherited aplastic anemia. in addition to supplying an in depth review of the pathophysiology of the sickness, the foreign group of authors covers all points of administration, together with the demonstrated ways of bone marrow transplantation and immunosuppressive therapy, new techniques akin to using hematopoietic progress components and escalated immunosuppression, and debatable concerns resembling stem mobilephone transplantation. additionally incorporated is a crucial foreign consensus rfile on remedy, and a last part concentrates at the inherited syndrome Fanconi's anemia. unique remedy directions are given, making this the definitive source for hematologists and different clinicians fascinated about the administration and supportive care of sufferers with aplastic anemia. Scientists attracted to bone marrow failure also will locate this a useful reference.

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Yamada, H. and Saito, H. (1985) Functional changes in marrow stromal cells in aplastic anemia. Acta Haematologica, 74, 65–9. , Beier, D. , Chu, T. , Lahm, H. , Leder, P. and Besmer, P. (1990) The hemopoietic growth factor KL is encoded by the SI locus and it’s the ligand of the c-kit receptor, the gene product of the W locus. Cell, 63, 225–33. , Thompson-Snipes, L. and Rennick, D. (1995) Flt-3/flk-2 ligand promotes the growth of murine stem cells and the expansion of colony-forming cells and spleen colony-forming units.

Blood, 78, 163–8. Nimer, S. , Leung, D. H. , Wolin, M. J. and Golde, D. W. (1994) Serum stem cell factor levels in patients with aplastic anemia. International Journal of Hematology, 60, 185–9. , Gratwohl, A. and Weis, J. (1985) Stimulatory serum factors in aplastic anaemia. British Journal of Haematology, 61, 499–512. , Harada, M. and Niho, Y. (1992) Levels of human serum granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor under pathological conditions. Biotherapy, 4, 147–53.

1982) Aplastic anemia: pathogenesis, diagnosis, treatment and prognosis. New England Journal of Medicine, 306, 645–50. Champlin, R. , Nimer, S. , Otte, D. H. and Golde, D. W. (1989) Treatment of refractory aplastic anemia with recombinant human granulocyte-macrophage colonystimulating factor. Blood, 73, 694–9. Demetri, G. D. and Griffin, J. D. (1991) Granulocyte colony-stimulating factor and its receptor. Blood, 78, 2791–808. Dexter, T. , Allen, T. D. and Lajtha, L. G. (1977) Conditions controlling the proliferation of hemopoietic stem cells in vitro.

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