Download Acute Myelogenous Leukemia (Contemporary Hematology) by Judith E. Karp PDF

By Judith E. Karp

This is a well timed compilation of latest ideas within the molecular pathogenesis and molecular treatment of acute myelogenous leukemia (AML). the point of interest is on chosen severe molecular determinants of AML pathogenesis and pathophysiology and the exploitation of those components through varied healing brokers and modalities. there's an emphasis all through at the bidirectional stream of data among the scientific and laboratory arenas.

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McCubrey JA. The Raf/MEKJERK signal transduction cascade as a target for chemotherapeutic intervention in leukemia. Leukemia 2002;16:486-507. 138. Cortes J, Albitar M, Thomas D, et al. Efficacy of the famesyl transferase inhibitor R115777 in chronic myeloid leukemia and other hematological malignancies. Blood 2003;101:1692-1697. 139. Karp JE. Farnesyl protein transferase inhibitors as targeted therapies for hematological malignancies. Semin HematoI2001;38:16-23. 140. Reed JC. Dysregulation of apoptosis in cancer.

In addition , because the C/EBPa N-terminus is required for inhibition of the cell cycle in fibroblast cells, loss of this region may enable C/EBPap30 to block differentiation without slowing proliferation. In addition, we find that C/EBPap30 retains the ability to activate the bcl-2 promoter and inhibit apoptosis. CIEBPaLZ oncoproteins, which cannot bind DNA, also activate the bcl-2 promoter. They may do so by interacting with the p50 subunit of nuclear factor (NF)-KB bound to KB promoter sites.

Wang S, Wang Q, Crute BE, Melnikova IN, Keller SR, Speck NA. Cloning and characterization of subunits of The T-cell receptor and murine leukemia virus enhancer core-binding factor. Mol Cell Bioi 1993;13: 3324-3339. Chapter 2 / Transcription Factors in AML 37 14. Nuchprayoon I, Meyers S, Scott LM, Suzow J, Hiebert S, Friedman AD. PEBP2/CBF, the murine homolog of the human myeloid AML I and PEBP2~/CBF~ oncoproteins, regulates the murine myeloperoxidase and neutrophil elastase genes in immature myeloid cells.

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