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Additional info for Acute Myelogenous Leukemia (Contemporary Hematology)
McCubrey JA. The Raf/MEKJERK signal transduction cascade as a target for chemotherapeutic intervention in leukemia. Leukemia 2002;16:486-507. 138. Cortes J, Albitar M, Thomas D, et al. Efficacy of the famesyl transferase inhibitor R115777 in chronic myeloid leukemia and other hematological malignancies. Blood 2003;101:1692-1697. 139. Karp JE. Farnesyl protein transferase inhibitors as targeted therapies for hematological malignancies. Semin HematoI2001;38:16-23. 140. Reed JC. Dysregulation of apoptosis in cancer.
In addition , because the C/EBPa N-terminus is required for inhibition of the cell cycle in fibroblast cells, loss of this region may enable C/EBPap30 to block differentiation without slowing proliferation. In addition, we find that C/EBPap30 retains the ability to activate the bcl-2 promoter and inhibit apoptosis. CIEBPaLZ oncoproteins, which cannot bind DNA, also activate the bcl-2 promoter. They may do so by interacting with the p50 subunit of nuclear factor (NF)-KB bound to KB promoter sites.
Wang S, Wang Q, Crute BE, Melnikova IN, Keller SR, Speck NA. Cloning and characterization of subunits of The T-cell receptor and murine leukemia virus enhancer core-binding factor. Mol Cell Bioi 1993;13: 3324-3339. Chapter 2 / Transcription Factors in AML 37 14. Nuchprayoon I, Meyers S, Scott LM, Suzow J, Hiebert S, Friedman AD. PEBP2/CBF, the murine homolog of the human myeloid AML I and PEBP2~/CBF~ oncoproteins, regulates the murine myeloperoxidase and neutrophil elastase genes in immature myeloid cells.